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Does incontrol intensity hurt12/27/2023 ![]() ![]() The present study aims at elucidating whether these two extreme ends of the spectrum of individual pain experience affect somatosensory processing.įMS is a chronic non-inflammatory musculoskeletal pain condition characterized by diffuse widespread pain and increased sensitivity to pressure at characteristic tender points. Along this line, pain-related catastrophizing encompassing magnification and feelings of helplessness to the experience of pain has been noticed as a frequently occurring symptom in chronic pain states like FMS (reviewed in ). While the latter valuate pain as positive and even pleasant under certain circumstances, for patients with FMS painful stimulation is highly aversive. In order to shed further light on the functional significance of this modulating effect, the present study investigates patients with FMS and subjects with MB. These data suggest that the observed increase of the late S1 component might represent a neurophysiological correlate of the alerting function of pain. Conversely, a preceding tactile stimulus results in reduced early as well as late S1 amplitudes. Interestingly, facilitation was indicated by increased somatosensory evoked amplitudes of late S1 and S2 but not of early S1 responses. demonstrated that preceding painful stimuli yield facilitation of subsequently applied non-painful tactile stimuli within S1 and S2 by means of MEG. Using a conditioning test stimulation paradigm, Ploner et al. Along this line, a modulating effect of painful stimuli on processing of tactile information has been evidenced in behavioural, , and in neurophysiological, ,, studies. Touch and pain are intimately related modalities. Funding by the Volkswagenstiftung has not altered our adherence to PLoS ONE policies on sharing data and materials. The VolkswagenStiftung is a non-commercial organization. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: They authors have declared that no competing interests exist. Please note that the Volkswagenstiftung is a non-commercial funder. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: The study was funded by the Volkswagenstiftung (I/80919) and by the Bundesministerium für Bildung und Forschung (BMFZ: 01GW0533 (TP 4)). Received: SeptemAccepted: NovemPublished: December 28, 2010Ĭopyright: © 2010 Pollok et al. PLoS ONE 5(12):Įditor: Izumi Sugihara, Tokyo Medical and Dental University, Japan (2010) Differential Effects of Painful and Non-Painful Stimulation on Tactile Processing in Fibromyalgia Syndrome and Subjects with Masochistic Behaviour. Additionally, in FMS patients the amount of attenuation was inversely correlated with catastrophizing tendency.Ĭitation: Pollok B, Krause V, Legrain V, Ploner M, Freynhagen R, Melchior I, et al. Attenuation as well as facilitation applied to cortical responses occurring at about 70 ms but not to early S1 or S2 responses. By contrast, in subjects with MB no attenuation but significant facilitation occurred. While in FMS patients significant attenuation following conditioning tactile stimulation was evident, no facilitation following painful stimulation was found. Tactile or brief painful cutaneous laser stimuli were applied as conditioning stimulus (CS) followed by a tactile test stimulus (TS) 500 ms later. Ten patients fulfilling the criteria for the diagnosis of FMS, 10 subjects with MB and 20 control subjects matched with respect to age, gender and handedness participated in the present study. To this end, the effect of painful and tactile stimulation on processing of subsequently applied tactile stimuli was investigated in patients with fibromyalgia syndrome (FMS) and in subjects with masochistic behaviour (MB) by means of a 122-channel whole-head magnetoencephalography (MEG) system. Since previous data suggest that cognitive processes might affect somatosensory processing in S1, the present study aims at investigating to what extent cortical reactivity is altered by the subjective estimation of pain.
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